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DNA ligase-3 (LIG3)
Function:
- interacts with DNA-repair protein XRCC1
- can correct defective DNA strand-break repair & sister chromatid exchange following treatment with ionizing radiation & alkylating agents
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m)
AMP + diphosphate + (deoxyribonucleotide)(n+m)
Structure:
- belongs to the ATP-dependent DNA ligase family
- contains 1 BRCT domain
- contains 1 PARP-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: testis, thymus, prostate & heart
General
ATP-dependent DNA ligase
phosphoprotein
Properties
SIZE: entity length = 922 aa
MW = 103 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger PARP-type
NAME: Zn finger PARP-type
SITE: 6-98
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T122}
Ser phosphorylation site {S123}
lysine residue {K421}
BRCA1 C-terminal (BRCT) motif
SITE: 846-922
References
- UniProt :accession P49916
- OMIM :accession 600940
- Wikipedia; Note: DNA ligase entry
http://en.wikipedia.org/wiki/DNA_ligase
Databases & Figures
OMIM 600940
UniProt P49916
PFAM correlations
Kegg hsa:3980
ENZYME 6.5.1.1
Figures/diagrams/slides/tables related to DNA ligase-3