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DMBT1 protein (deleted in malignant brain tumors 1 protein, glycoprotein 340, Gp-340, surfactant pulmonary-associated D-binding protein, DMBT1, GP340)
Function:
1) tumor suppressor gene
- brain cancer, lung cancer, esophageal cancer, gastric cancer, colorectal cancer
2) mucosal defense system (putative)
3) cellular immune defense (putative)
4) epithelial differentiation
5) opsonin receptor or SFTPD & SPAR in macrophage tissues (putative)
6) liver regeneration (putative)
7) binding protein in saliva for the regulation of taste sensation (putative)
8) binds SFTPD & SPAR (Ca+2-dependent)
Compartment:
- secreted
- some isoforms may be membrane-bound
- lumenal aspect of crypt cells in small intestine
- lumenal aspect of surface epithelial cells (colon)
- formed in the ducts of von Ebner gland, & released into the fluid bathing the taste buds contained in taste papillae
Alternative splicing: named isoforms=5
Expression:
- highly expressed in alveolar & macrophage tissues.
- expressed in lung, trachea, salivary gland, small intestine, stomach
- expressed in certain cells of islets of Langerhans
- expressed at highest levels in lung & small intestine
- expressed in fetal lung, intestine & skin
- secreted to the extracellular matrix (ECM) in certain fetal epithelia
- induced by in intestinal epithelial cells in response to proinflammatory stimuli including TNF-alpha & LPS
Polymorphism:
- the number of SRCR & SRCR-interspersed domains is polymorphic in a variety of tumors & may represent the major site of alterations in cancer
Genetics:
- derived from same gene as GP340 which binds lung surfactant protein D
Pathology:
1) allelic loss found in gliomas
a) 25% of medulloblastomas
b) 59% of glioblastomas [1]
2) loss or reduction of DMBT1 expression associated with
a) esophageal carcinoma
b) gastric carcinoma
c) lung carcinoma
d) colorectal carcinomas
3) a deletion allele of DMBT1 which lacks 5 SRCR domains is associated with an increased risk of Crohn disease
Related
DMBT1 (deleted in malignant brain tumors) gene
General
scavenger receptor cysteine-rich (SRCR) superfamily protein
Properties
SIZE: entity length = 1785 aa
MW = 196 kD
MOTIF: ZP domain
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*2}
cysteine residue {*2}
MODIFICATION: cysteine residue {*1}
SRCR domain (9)
CUB domain
N-glycosylation site
cysteine-rich region
Database Correlations
OMIM correlations
UniProt Q9UGM3
PFAM correlations
Entrez Gene 1755
Kegg hsa:1755
References
- Mollenhauer J et al
DMBT1, a new member of the SRCR superfamily, on chromosome
10q25.3-26.1 is deleted in malignant brain tumours.
Nature Genetics 17:32-9, 1997
PMID: 9288095
- OMIM :accession 601969
- UniProt :accession Q9UGM3
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/DMBT1ID309ch10q26.htm