deleted in lung & esophageal cancer protein 1; deleted in lung cancer protein 1; DLC-1 (DLEC1, DLC1)

Function: - may act as a tumor suppressor by inhibiting cell proliferation Compartment: cytoplasm Alternative splicing: - named isoforms=3 - at least 6 differentially spliced products may exist - specific splice isoform may be increased in cancer cell lines & primary cancers Expression: - expressed in all tissues examined - expression is highest in prostate & testis Pathology: - DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of different cancers, including esophageal cancer, renal cell carcinoma & lung cancer - defects in DLEC1 are a cause of lung cancer - DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of lung cancer - defects in DLEC1 are a cause of esophageal cancer - DLEC1 silencing due to promoter methylation & aberrant transcription are implicated in the development of esophageal cancer

Properties

SIZE: entity length = 1755 aa MW = 196 kD COMPARTMENT: cytoplasm

Database Correlations

OMIM correlations UniProt Q9Y238 Entrez Gene 9940 Kegg hsa:9940

References

UniProt Q9Y238