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Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3 (DKK3, REIC, UNQ258/PRO295)
Function:
- antagonizes canonical Wnt signaling by inhibiting LRP5 &/or LRP6
- interaction with Wnt & by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 &/or LRP6
- DKKs play a role in vertebrate development, where they locally inhibit Wnt regulated processes such as anteroposterior axial patterning, limb development, somitogenesis & eye formation
- in adults, Dkks are implicated in bone formation
- interacts with LRP5 & LRP6 (putative)
Structure:
- N-glycosylated & O-glycosylated
- the C-terminal cysteine-rich domain mediates interaction with LRP5 & LRP6 (putative)
- belongs to the dickkopf family
Compartment: secreted
Expression:
- highest expression in heart, brain, & spinal cord
Pathology:
- Dkks are implicated in bone disease, cancer & Alzheimer disease
General
Dickkopf homolog
Properties
SIZE: entity length = 350 aa
MW = 38 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
O-glycosylated at one site {26-46}
coiled coil {40-84}
N-glycosylation site {N96}
N-glycosylation site {N106}
N-glycosylation site {N121}
DKK-type Cys-1 {147-195}
N-glycosylation site {N204}
DKK-type Cys-2 {208-284}
MOTIF: cysteine residue {C208}
MODIFICATION: cysteine residue {C220}
cysteine residue {C214}
MODIFICATION: cysteine residue {C231}
cysteine residue {C219}
MODIFICATION: cysteine residue {C265}
cysteine residue {C220}
MODIFICATION: cysteine residue {C208}
cysteine residue {C231}
MODIFICATION: cysteine residue {C214}
cysteine residue {C241}
MODIFICATION: cysteine residue {C273}
cysteine residue {C265}
MODIFICATION: cysteine residue {C219}
cysteine residue {C273}
MODIFICATION: cysteine residue {C241}
alanine-rich region {338-343}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 605416
UniProt Q9UBP4
Pfam PF04706
Entrez Gene 27122
Kegg hsa:27122
References
UniProt :accession Q9UBP4