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protein deglycase DJ-1; DJ-1; oncogene DJ1; parkinson disease protein 7 (PARK7)
Function:
- unknown
- may be involved in RAS related signal transduction;
- may be involved in oxidative stress response
- may protect neurons against oxidative stress
- binds to PIAS proteins;
- sumoylated at lysine 130
- positive regulator of androgen receptor- dependent transcription
- prevents aggregation of SNCA
- weak transforming activity
- binds DJBP,PIAS2.
- component of ternary complex containing PARK7, DJBP, AR
Compartment:
- cytoplasm
- associated with mitochondria in some cells after oxidative stress
Expression:
- expressed in pancreas, kidney, skeletal muscle, liver, testis heart > placenta, brain (astrocytes)
Pathology:
- detected in tau inclusions in brains from patients with neurodegenerative disease
- mutations seen in early onset autosomal recessive Parkinson's disease - PARK7
Related
PARK7 gene mutation
Parkinson's disease 7 (PARK7)
General
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 189 aa
MW = 20 kD
COMPARTMENT: mitochondria
cytoplasm
cell nucleus
MOTIF: cysteine residue {C46}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C53}
MODIFICATION: palmitate
COMPARTMENT: membrane
Tyr phosphorylation site {Y67}
cysteine residue {C106}
cysteine residue {C106}
MODIFICATION: palmitate
COMPARTMENT: membrane
histidine residue {H126}
Database Correlations
OMIM correlations
MORBIDMAP 602533
UniProt Q99497
Pfam PF01965
Entrez Gene 11315
Kegg hsa:11315
References
- Bonifati V et al
Mutations in the DJ-1 gene associated with autosomal recessive
early-onset parkinsonism.
Science 299:256-59, 2003
PMID: 12446870
- UniProt :accession Q99497