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distal acquired demyelinating symmetric neuropathy (DADS)

Etiology: - phenotype of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Clinical manifestations: - symmetric, predominantly motor impairment without ataxia & tremor - preserved proprioception Laboratory: - elevated CSF protein - case report: 340 mg/dL (12-60 mg/dL) [2] Special laboratory: - electromyography - absence of compound muscle action potentials over the feet &lower leg muscles [2] - nerve conduction study - preserved sural sensory nerve action potential - decrease in evoked electrical excitability at site of femoral nerve stimulation [2] Management: - case report: refractory to treatment [2]

General

chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

References

  1. Katz JS, Saperstein DS, Gronseth G, Amato AA, Barohn RJ. Distal acquired demyelinating symmetric neuropathy. Neurology. 2000 Feb 8;54(3):615-20. PMID: 10680792 https://www.neurology.org/doi/10.1212/wnl.54.3.615
  2. Khodulev VI, Ponomarev VV, Stepanova JI. Distal Acquired Demyelinating Symmetric Neuropathy Associated with Decreased Electrical Excitability of the Femoral Nerves. Maedica (Bucur). 2021 Dec;16(4):707-712. PMID: 35261675 PMCID: PMC8897776 Free PMC article.