Search
disks large-associated protein 2; DAP-2; SAP90/PSD-95-associated protein 2; SAPAP2; PSD-95/SAP90-binding protein 2 (DLGAP2, DAP2)
Function:
- may play a role in the molecular organization of synapses & neuronal cell signaling
- could be an adapter protein linking ion channel to the subsynaptic cytoskeleton
- may induce enrichment of PSD-95/SAP90 at the plasma membrane
- interacts with DLG1 & DLG4/PSD-95 (putative)
Structure: belongs to the SAPAP family
Compartment:
- cell membrane; peripheral membrane protein (putative)
- cell junction, synapse, postsynaptic cell membrane, postsynaptic density (putative)
- postsynaptic density of neuronal cells (putative)
Alternative splicing: named isoforms=3
Expression: expressed in brain & kidney
Related
disks large homolog 4; postsynaptic density protein 95; PSD-95; synapse-associated protein 90; SAP90 (DLG4, PSD95)
General
phosphoprotein
Properties
SIZE: entity length = 1054 aa
MW = 118 kD
MOTIF: Ser phosphorylation site {S224}
Tyr phosphorylation site {Y308}
Ser phosphorylation site {S436}
Ser phosphorylation site {S446}
Ser phosphorylation site {S449}
Ser phosphorylation site {S570}
Ser phosphorylation site {S740}
Ser phosphorylation site {S1007}
Ser phosphorylation site {S1035}
Ser phosphorylation site {S1042}
Database Correlations
OMIM 605438
UniProt Q9P1A6
Pfam PF03359
Entrez Gene 9228
Kegg hsa:9228
References
UniProt :accession Q9P1A6