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disaccharidase deficiency

Etiology: - lactase deficiency - maltase deficiency - sucrase-isomaltase deficiency Pathology: - inability to digest lactose, maltose &/or sucrose - malabsorption Clinical manifestations: - bloat - diarrhea - borborygmi Laboratory: - definitive diagnosis is a small bowel biopsy (just distal to the duodenum) & small bowel enzyme tests - 2 biosies: 1 for histopathology, 1 for enzyme analysis Management: - dietary modification

General

enzyme deficiency

References

  1. Peterson P Disaccharidase Deficiency: An Overlooked Digestive Disorder. Quest Diagnostics http://education.questdiagnostics.com/insights/24
  2. Congenital Sucrase-Isomaltase Deficiency. Genetic and Rare Diseases Information Center. National Institutes of Health. Available at: http://rarediseases.info.nih.gov/GARD/QnASelected.aspx?diseaseID=7710#4522