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disrupted in renal carcinoma protein 2 (DIRC2)
Structure:
- belongs to the major facilitator superfamily
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- expressed in proximal tubular cells of the kidney
Pathology:
- chromosomal translocation t(2;3)(q35;q21) involving DIRC2 is found in familial renal cell carcinoma 1 (RCC1)
General
glycoprotein
major facilitator superfamily (MFS)
transmembrane 12 protein
Properties
SIZE: MW = 52 kD
entity length = 478 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {52-72}
transmembrane domain {90-110}
transmembrane domain {118-138}
transmembrane domain {156-176}
transmembrane domain {185-205}
N-glycosylation site {N209}
transmembrane domain {230-250}
transmembrane domain {282-302}
transmembrane domain {315-335}
transmembrane domain {348-368}
transmembrane domain {385-405}
transmembrane domain {415-435}
transmembrane domain {443-463}
Database Correlations
OMIM correlations
UniProt Q96SL1
References
- UniProt :accession Q96SL1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/DIRC2ID497.html