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diphenoxylate
Used in combination with atropine in Lomotil.
Pharmacokinetics:
1) good bioavailability
2) extensively metabolized to an inactive metabolite
3) elimination 1/2life is 12-14 hours
4) excreted primarily in urine
Mechanism of action:
1) constipating meperidine congener
2) lacks analgesic activity
General
anti-motility agent; antiperistaltic agent
Properties
MISC-INFO: elimination route LIVER
1/2life 12-14 HOURS
Database Correlations
PUBCHEM correlations
References
Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998 - not on National VA formulary
Component-of
atropine/diphenoxylate (Lomotil, Lonox)