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dinutuximab (Unituxin)
Indications:
- treatment of high-risk neuroblastoma in combination with GM-CSF, IL-2 & 13-cis retinoic acid
Dosage:
- 17.5 mg/m2/day IV infused over 10-20 hours for 4 consecutive days for up to 5 cycles
Injection: 17.5 mg/5 mL (3.5 mg/mL) in a single-use vial
Adverse effects:
common >= 25%
- infusion reactions
- capillary leak syndrome
- hypotension
- neuropathy
- severe neuropathic pain -other
- pyrexia, vomiting, diarrhea, urticaria,
- thrombocytopenia, lymphopenia, neutropenia anemia,
- hyponatremia, hypokalemia, hypocalcemia
- abnormal liver function tests, hypoalbuminemia,
Mechanism of action:
- monoclonal antibody
- binds to glycolipid disialoganglioside GD2 on the surface of neuroblastoma cells [3]
- induces lysis of GD2-expressing cells through antibody-dependent cell-mediated cytotoxicity & complement-dependent cytotoxicity [3]
Interactions
drug adverse effects of pharmaceutical monoclonal antibodies
General
antineoplastic monoclonal antibody
References
- FDA News Release. March 10, 2015
FDA approves first therapy for high-risk neuroblastoma
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm437460.htm
- Prescribing information
http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/125516s000lbl.pdf
- Medscape: dinutuximab (Rx) - Unituxin
http://reference.medscape.com/drug/unituxin-dinutuximab-1000005