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dihydrofolate reductase (DHFR, tetrahydrofolate dehydrogenase)
Function:
- cofactor biosynthesis; tetrahydrofolate biosynthesis
- tetrahydrofolate from 7,8-dihydrofolate
- reaction catalyzed by DHFR represents an essential step for de novo glycine & purine synthesis, DNA precursor synthesis, & for the conversion of dUMP to dTM
5,6,7,8-tetrahydrofolate + NADP+
7,8-dihydrofolate + NADPH
Structure:
- belongs to the dihydrofolate reductase family
- contains 1 DHFR (dihydrofolate reductase) domain
Interactions
molecular events
Related
dihydrofolate reductase [DHFR] primary response gene
General
amine oxidoreductase
dehydrogenase
Properties
SIZE: entity length = 187 aa
MW = 21 kD
MOTIF: DHFR {4-185}
Database Correlations
OMIM 126060
UniProt P00374
Pfam PF00186
KEGG correlations
ENZYME 1.5.1.3
References
- UniProt :accession P00374
- Wikipedia; Note: Dihydrofolate reductase entry
http://en.wikipedia.org/wiki/Dihydrofolate_reductase