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digital protein truncation assay

Principle: - assay tests for mutations in the adenomatous polyposis coli (APC) gene in feces - mutations in the APC gene are found in both familial & sporadic colorectal carcinoma - sensitivity: 61% for adenocarcinoma, 50% for adenoma > 1 cm - specificity: 100%

Related

adenocarcinoma of the colon &/or rectum familial adenomatous polyposis [FAP] gene

General

fecal DNA testing

References

  1. Traverso G et al Detection of APC mutations in fecal DNA from patients with colorectal tumors. N Engl J Med. 2002 Jan 31;346(5):311-20. PMID: 11821507