Search
dienestrol (DV cream, Cycladiene)
Indications:
- symptomatic management of menopause symptoms
- atrophic vaginitis
- atrophy of vulva
Dosage:
- vaginal:
1) 1-2 applications/day for 2 weeks
2) 1 application/day for 2 additional weeks
3) maintenance: 1 application 1-3 times/week for 3 weeks each month
Vaginal cream (with applicator): 0.01% (30 g)
Pharmacokinetics:
- topical vaginal application is associated with extensive absorption into the systemic circulation
Adverse effects:
1) not common (1-10%)
- anorexia, abdominal cramping, peripheral edema, breast tenderness, breast enlargement
2) uncommon (< 1%)
- hypertension, thromboembolism, stroke, myocardial infarction, migraine, dizziness, anxiety, depression, headache, chloasma, melasma, rash, decreased glucose tolerance, alteration in menses flow, nausea, GI distress, increased triglycerides, increased LDL cholesterol, cholestatic jaundice, increased susceptibility to Candida infection
Interactions
drug adverse effects of estrogens
General
estrogen
Properties
MISC-INFO: pregnancy-category X
Database Correlations
PUBCHEM correlations
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference