dehydrogenase/reductase SDR family member 8 (17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17-beta- HSD XI, 17betaHSDXI, 17bHSD11, 17betaHSD11, retinal short-chain dehydrogenase/reductase 2, retSDR2, cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL tumor antigen HD-CL-03, DHRS8, HSD17B11, PAN1B, PSEC0029, UNQ207/PRO233)

Function: - converts androstan-3-alpha,17-beta-diol to androsterone in vitro - role in androgen metabolism during steroidogenesis - may act by metabolizing compounds that stimulate steroid synthesis &/or by generating metabolites that inhibit it - no activity toward DHEA, 4-androste-3,17-dione or testosterone Structure: - belongs to the short-chain dehydrogenases/reductases (SDR) family Compartment: secreted Expression: - widely expressed - highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary, heart - expressed in steroidogenic cells including syncytiotrophoblasts, Leydig cells, sebaceous gland & granulosa cells of the dominant follicle & corpus luteum - in lung, expressed in ciliated epithelium & in acini of adult trachea, in bronchioles, but not in alveoli - in eye, expressed in nonpigmented epithelium of the ciliary body > inner nuclear layer of the retina Pathology: - tumor-associated antigen in cutaneous T-cell lymphoma

General

17 beta-hydroxysteroid dehydrogenase (estradiol 17 beta-dehydrogenase, HSD17B1) dehydrogenase/reductase SDR family (DHRS) secreted protein

Properties

SIZE: MW = 33 kD entity length = 300 aa COMPARTMENT: smooth endoplasmic reticulum MOTIF: signal sequence {1-19} binding site SITE: 172-172 FOR-BINDING-OF: Substrate tyrosine residue {Y185}

Database Correlations

UniProt Q8NBQ5 Pfam PF00106

References

UniProt :accession Q8NBQ5