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dehydroepiandrosterone sulfate (DHEA-SO4)
DHEA-SO4 is derived largely from the adrenals (95% in males/100% in females). Some may be produced by the testes. None is produced by the ovaries. Within the adrenals DHEA & its sulfate are produced by the zona fasciculata & zona reticularis of the adrenal cortex. Adrenal production is regulated by ACTH.
DHEA-SO4 is weakly androgenic, but is metabolized in peripheral tissues to testosterone & dihydrotestosterone. Plasma levels of DHEA-SO4 are 1000 times that of DHEA & 10 times that of cortisol. Unlike DHEA, DHEA sulfate does NOT exhibit diurnal variation. Unlike testosterone. DHEA-SO4 does NOT circulate bound to sex hormone binding globulin.
DHEA-sulfate serum levels decline progressively with aging in cross-sectional studies. However interindividual variability in serum DHEA-sulfate levels is much larger than any age-related change.
DHEA-sulfate levels are increased with hyperthyroidism & decreased with hypothyroidism. [3]
Interactions
drug adverse effects of androgens
Related
dehydroepiandrosterone (DHEA) sulfate in serum/plasma
General
dehydroepiandrosterone; prasterone (DHEA, Aslera, Intrarosa)
sulfate ester
Database Correlations
PUBCHEM correlations
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 243
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Solomon DH, in: UCLA Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001
Substructures
dehydroepiandrosterone; prasterone (DHEA, Aslera, Intrarosa)