Search
detemir (Levemir)
Available 2006.
Dose:
1) 0.1-0.2 units/kg SC qPM
2) 10 units SC QD-BID
100 units/mL
10 mL vial
3 mL disposable FlexPen
Do NOT mix with other insulins
can be stored in prefilled syringes for up to 42 days, (contrast with glargine)
Pharmacokinetics:
1) long-acting insulin analog like glargine (Lantus)
2) peak 6-8 hours
3) duration: dose-dependent; up to 24 hours
4) binds albumin
Adverse effects:
- less acidic than Lantus, thus burns less on injection
Notes:
- hypoglycemia & glycemic control no better with detemir than with neutral protamine Hagedorn insulin [2]
Interactions
drug adverse effects of hypoglycemic agents
General
long-acting insulin
References
- Prescriber's Letter 12(8): 2005
Comparison of Insulins
Detail-Document#: 210803
(subscription needed) http://www.prescribersletter.com
- Lipska KJ, Parker MM, Moffet HH, Huang ES, Karter AJ
Association of initiation of basal insulin analogs vs neutral
protamine Hagedorn insulin with hypoglycemia-related emergency
department visits or hospital admissions and with glycemic
control in patients with type 2 diabetes.
JAMA 2018 Jul 3; 320:53.
PMID: 29936529
https://jamanetwork.com/journals/jama/fullarticle/2685850
- Crowley MJ, Maciejewski ML.
Revisiting NPH insulin for type 2 diabetes: Is a step back
the path forward?
JAMA 2018 Jul 3; 320:38.
PMID: 29936528
https://jamanetwork.com/journals/jama/fullarticle/2685849