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desmoglein-1; cadherin family member 4; desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen (DSG1, CDHF4)
Function:
- component of intercellular desmosome junctions
- involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion
Structure:
- Ca+2 may be bound by the cadherin-like repeats
- contains 4 cadherin domains
Compartment:
- cell membrane; single-pass type 1 membrane protein (putative)
- cell junction, desmosome
Expression: epidermis, tongue, tonsil & esophagus
Pathology:
- defects in DSG1 are the cause of palmoplantar keratoderma striate type 1
Related
pemphigus foliaceus
General
desmoglein (desmosomal glycoprotein)
human longevity protein
phosphoprotein
Properties
SIZE: entity length = 1049 aa
MW = 114 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
N-glycosylation site {N36}
cadherin domain {50-158}
MOTIF: N-glycosylation site {N110}
cadherin domain {159-270}
MOTIF: N-glycosylation site {N180}
cadherin domain {271-385}
cadherin domain {386-497}
transmembrane domain {549-569}
Ser phosphorylation site {S579}
Desmoglein {813-839}
Desmoglein {840-869}
Desmoglein {870-899}
Desmoglein {900-927}
Desmoglein {928-956}
serine-rich region {969-1019}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM correlations
UniProt Q02413
PFAM correlations
Entrez Gene 1828
Kegg hsa:1828
References
- UniProt :accession Q02413
- Entrez Gene :accession 1828