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desmocollin-1; desmosomal glycoprotein 2/3; DG2/DG3 (DSC1 CDHF1)
Function:
1) component of intercellular desmosome junctions
2) involved in the interaction of plaque proteins & intermediate filaments
3) mediating cell-cell adhesion
4) may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms
5) linked to the keratinization of epithelial tissues
Structure:
1) Ca+2 may be bound by the cadherin-like repeats
2) contains 5 cadherin domains
Compartment:
- cell membrane; single-pass type 1 membrane protein
- cell junction, desmosome
Alternative splicing: named isoforms=2; 1A (DG2); 1B (DG3)
Expression:
- strongly expressed in epidermis, less in lymph node & tongue
General
desmocollin
phosphoprotein
Properties
SIZE: entity length = 894 aa
MW = 100 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-29}
cadherin domain {135-242}
MOTIF: N-glycosylation site {N165}
cadherin domain {243-354}
cadherin domain {355-471}
MOTIF: Thr phosphorylation site {T385}
cadherin domain {472-575}
MOTIF: N-glycosylation site {N546}
cadherin domain {576-682}
transmembrane domain {692-714}
Database Correlations
OMIM 125643
UniProt Q08554
PFAM correlations
Entrez Gene 1823
References
- OMIM :accession 125643
- Entrez Gene :accession 1823