des-gamma-carboxy-prothrombin; protein induced by vitamin K absence or antagonist II

Structure: - prothrombin without gamma-carboxyglutamate residues from post-translational modification by vitamin K-dependent carboxylase Pathology: - form of prothrombin resulting from vitamin K deficiency or vitamin K antagonism

Properties

GENERAL: prothrombin RELATED: prothrombin gene des-gamma-carboxy-prothrombin in serum SIZE: entity length = 622 aa MW = 70 kD COMPARTMENT: plasma FORM: des-gamma-carboxy-prothrombin MOTIF: signal sequence {1-24} Gla {44-89} MOTIF: cysteine residue {C60} MODIFICATION: cysteine residue {C65} cysteine residue {C65} MODIFICATION: cysteine residue {C60} cysteine residue {C90} MODIFICATION: cysteine residue {C103} cysteine residue {C103} MODIFICATION: cysteine residue {C90} Kringle 1 {108-186} MOTIF: cysteine residue {C108} MODIFICATION: cysteine residue {C186} N-glycosylation site {N121} cysteine residue {C129} MODIFICATION: cysteine residue {C169} N-glycosylation site {N143} cysteine residue {C157} MODIFICATION: cysteine residue {C181} cysteine residue {C169} MODIFICATION: cysteine residue {C129} cysteine residue {C181} MODIFICATION: cysteine residue {C157} cysteine residue {C186} MODIFICATION: cysteine residue {C108} proteolytic site {198-199} Kringle 2 {213-291} MOTIF: cysteine residue {C213} MODIFICATION: cysteine residue {C291} cysteine residue {C234} MODIFICATION: cysteine residue {C274} cysteine residue {C262} MODIFICATION: cysteine residue {C286} cysteine residue {C274} MODIFICATION: cysteine residue {C234} cysteine residue {C286} MODIFICATION: cysteine residue {C262} cysteine residue {C291} MODIFICATION: cysteine residue {C213} proteolytic site {327-328} cysteine residue {C336} MODIFICATION: cysteine residue {C-INTERCHAIN} proteolytic site {363-364} S1 domain {364-618} MOTIF: cysteine residue {C391} MODIFICATION: cysteine residue {C407} histidine residue {H406} cysteine residue {C407} MODIFICATION: cysteine residue {C391} N-glycosylation site {N416} aspartate residue {D462} cysteine residue {C536} MODIFICATION: cysteine residue {C550} cysteine residue {C550} MODIFICATION: cysteine residue {C536} binding site SITE: 551-573 FOR-BINDING-OF: HIGH motif cysteine residue {C564} MODIFICATION: cysteine residue {C594} serine residue {S568} cysteine residue {C594} MODIFICATION: cysteine residue {C564} PRECURSOR-FOR: thrombin COMPARTMENT: plasma STATE: active state COMPONENT-OF: factor ix/factor vii/factor x/protein c/protein s/prothrombin/prothrombin complex concentrate prothrombin complex concentrate phosphatidylserine-prothrombin complex MISC-INFO: 1/2life 50 HOURS

Database Correlations

OMIM correlations MORBIDMAP 176930 UniProt P00734 PFAM correlations Entrez Gene 2147 Kegg hsa:2147 ENZYME 3.4.21.5