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derlin-3 (degradation in endoplasmic reticulum protein 3, Der1-like protein 3, DERtrin-3, DERL3, C22orf14, DER3, LLN2)
Function:
1) endoplasmic reticulum-associated degradation
a) misfolded lumenal glycoproteins, but NOT that of misfolded non-glycoproteins
2) forms channel that allows the retrotranslocation of misfolded glycoproteins into cytosol where they are ubiquitinated & degraded by the proteasome (putative)
3) mediates interaction between VCP & the degradation substrate
4) forms homo- & heterooligomers with DERL2 & DERL1
5) interacts with VCP & EDEM1
6) up-regulated in the unfolded protein response
- via the ERN1-XBP1 pathway
Compartment: endoplasmic reticulum membrane
Alternative splicing: named isoforms=4
Expression:
- unlike DERL1 & DERL2, restricted to several tissues
- expressed in placenta, pancreas, spleen, small intestine
General
derlin (degradation in endoplasmic reticulum protein, Der1-like protein, DERtrin)
Properties
SIZE: MW = 27 kD
entity length = 235 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: cytoplasmic domain {1-22}
transmembrane domain {23-43}
exoplasmic loop {44-58}
transmembrane domain {59-79}
cytoplasmic loop {80-98}
transmembrane domain {99-119}
exoplasmic loop {120-157}
transmembrane domain {158-178}
cytoplasmic domain {179-235}
Database Correlations
UniProt Q96Q80
Pfam PF04511
References
UniProt :accession Q96Q80