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derlin-2 (degradation in endoplasmic reticulum protein 2, Der1-like protein 2, DERtrin-2, DERL2, F-LANa, F-LAN-1, DERL2, DER2, FLANA, CGI-101, SBBI53)
Function:
1) endoplasmic reticulum-associated degradation
a) misfolded lumenal glycoproteins, but NOT that of misfolded non-glycoproteins
2) forms channel that allows the retrotranslocation of misfolded glycoproteins into cytosol where they are ubiquitinated & degraded by the proteasome (putative)
3) mediates interaction between VCP & the degradation substrate
4) forms homo- & heterooligomers with DERL2 & DERL1
5) interacts with SELS, VCP & EDEM1
6) up-regulated in the unfolded protein response
- via the ERN1-XBP1 pathway
Compartment: endoplasmic reticulum membrane
Expression: ubiquitous
Pathology:
- overexpressed in hepatocarcinomas
General
derlin (degradation in endoplasmic reticulum protein, Der1-like protein, DERtrin)
Properties
SIZE: MW = 28 kD
entity length = 239 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: cytoplasmic domain {1-57}
transmembrane domain {58-78}
exoplasmic loop {79-96}
transmembrane domain {97-117}
cytoplasmic loop {118-150}
transmembrane domain {151-171}
exoplasmic loop {172-172}
transmembrane domain {173-193}
cytoplasmic domain {194-239}
Database Correlations
UniProt Q9GZP9
Pfam PF04511
References
UniProt :accession Q9GZP9