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Depo-Provera

Indications: 1) contraception 2) endometriosis Dosage:150 mg IM# every 3 months* # Depo-subQ Provera-104 approved for SQ injection [5] * abstain from intercourse for 7 days may be initiated at any time during the menstrual cycle no data on harm to fetus if initiated during pregnancy [4] Injection: (suspension) 150 mg/mL (1 mL); 400 mg/mL (2.5 & 10 mL). Adverse effects: 1) see medroxyprogesterone (Provera) 2) bone loss with Depo-Provera [1] - only partially reversible [3] 3) increased risk of sexually transmitted disease with Depo Provera [2], including HIV [7] 4) increased risk of venous thromboembolism []

General

progestin-only contraceptive

References

  1. Journal Watch 21(21):173, 2001 Berenson et al Obstet Gynecol 98:576, 2001
  2. Journal Watch 24(19):149, 2004 Morrison CS et al, Hormonal conraceptive use, cervical ectopy and the acquisition of cervical infection, Sex Transm Dis 31:561, 2004
  3. Prescriber's Letter 12(1): 2005 Depo-Provera (Medroxyprogesterone Injectable Suspension) and Bone Loss Detail-Document#: 210111 (subscription needed) http://www.prescribersletter.com
  4. Journal Watch 25(8):66-67, 2005 Sneed R, Westhoff C, Morroni C, Tiezzi L. A prospective study of immediate initiation of depo medroxyprogesterone acetate contraceptive injection. Contraception. 2005 Feb;71(2):99-103. PMID: 15707558
  5. Prescriber's Letter 12(5): 2005 New Formulation: Depo-subQ Provera 104 Detail-Document#: 210513 (subscription needed) http://www.prescribersletter.com
  6. Mantha S et al Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis. BMJ 2012;345:e4944 PMID: 22872710 http://www.bmj.com/content/345/bmj.e4944
  7. Ralph LJ et al Hormonal contraceptive use and women's risk of HIV acquisition: a meta-analysis of observational studies. The Lancet Infectious Diseases. Online: Jan 2015 PMID: 25578825 http://www.thelancet.com/journals/lancetid/article/PIIS1473-3099%2814%2971052-7/abstract

Components

medroxyprogesterone actetate; acetoxymethylprogesterone (Provera, Cycrin, Amen)