Search
deoxycytidylate [dCMP] deaminase (DCTD)
Function:
- supplies nucleotide substrate for thymidylate synthetase
- allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP & dTTP
dCMP + H2O dUMP + NH3
Cofactor: Zn+2
Structure:
- homohexamer
- belongs to the cytidine & deoxycytidylate deaminase family
General
nucleotide deaminase
Properties
SIZE: entity length = 178 aa
MW = 20 kD
MOTIF: Tyr phosphorylation site {Y79}
Zn+2-binding site
SITE: 84-84
glutamate residue {E86}
Zn+2-binding site
SITE: 110-110
Zn+2-binding site
SITE: 113-113
Database Correlations
OMIM 607638
UniProt P32321
Pfam PF00383
Entrez Gene 1635
ENZYME 3.5.4.12
References
UniProt :accession P32321