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dense breast tissue
Clinical significance:
1) risk factor for breast cancer [1]
2) genetically determined
3) 4 categories of mammographic density [2]
a) almost entirely fat (< 25%)
b) scattered fibroglandular densities (25-50%)
c) heterogenously dense (51-75%)
d) extremely dense (>75%)
4) some states may require informing women whether they have dense breast tissue - and if so, that dense tissue may hide tumors on mammograms & increase one's risk for breast cancer [3]
Radiology:
- digital screening mammography [4]
Related
screening for breast cancer
General
abnormal imaging
References
- Journal Watch 22(21):159, 2002
Boyd NF et al
Heritability of mammographic density, a risk factor for
breast cancer.
N Engl J Med 347:886, 2002
PMID: 12239257
- Chen J et al,
Projecting absolute invasive breast cancer risk in white
women with a model that includes mammographic density.
J Natl Cancer Inst 2006, 98:1215
PMID: 16954474
- Barlow WE et al,
Prospective breast cancer risk prediction model for women
undergoing screening mammography
J Natl Cancer Inst 2006, 98:1204
PMID: 16954473
- Bondy ML & Newman LA
Assessing breast cancer risk: Evolution of the Gail Model.
J Natl Cancer Inst 2006, 98:1172
PMID: 16954464
- Grady D
New Laws Add a Divisive Component to Breast Screening
New York Times, Oct 24, 2012
http://www.nytimes.com/2012/10/25/health/laws-tell-mammogram-clinics-to-address-breast-density.html
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015