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demyelinating disease
Classification:
- idiopathic inflammatory CNS demyelinating disorders are defined by their distribution, clinical symptoms, severity & tendency to relapse
Epidemiology:
- multiple sclerosis is the most common CNS demyelinating disorder
Comparative biology:
- miconazole & clobetasol promote remyelination in mouse demyelinating disease
- these 2 agents induced mouse oligodendrocyte-progenitor stem cells to turn into myelin-producing oligodendrocytes [2]
Interactions
disease interactions
Related
demyelination
Specific
acute hemorrhagic leukoencephalopathy
autosomal dominant adult-onset leukodystrophy (autosomal dominant Pelizaeus-Merzbacher disease)
central pontine myelinolysis (osmotic demyelination syndrome)
encephalomyelitis
inflammatory demyelinating polyneuropathy
Marchiafava-Bignami disease
multiple sclerosis (MS); includes clinically isolated syndrome
Pelizaeus-Merzbacher disease
progressive multifocal leukoencephalopathy (PML)
transverse myelitis
General
neuroinflammatory disease
References
- Medical Knowledge Self Assessment Program (MKSAP) 15,
American College of Physicians, Philadelphia 2009
- Najm FJ et al.
Drug-based modulation of endogenous stem cells promotes
functional remyelination in vivo.
Nature 2015 Jun 11; 522:216.
PMID: 25896324