Demulen 1/50

50 ug ethinyl estradiol (estrogen) plus 1 mg ethynodiol (progestin) Indications: 1) prevention of pregnancy 2) treatment of hypermenorrhea 3) endometriosis 4) female hypogonadism Contraindications: pregnancy-category X safety in lactation - Pharmacokinetics: elimination: liver Adverse effects: 1) common (> 10%) - nausea, peripheral edema, breast enlargement, breast tenderness, anorexia, bloating 2) not common (1-10%) - vomiting, diarrhea, increased libido, headache 3) uncommon (< 1%) - intolerance to contact lenses, breast tumors, amenorrhea, alterations in mestrual flow, hypertension, thromboembolism, stroke, myocardial infarction, edema, depression, dizziness, anxiety, chloasma, melasma, rash, hyperglycemia, GI distress, increased serum triglycerides, increased LDL, cholestatic jaundice, increased susceptibility to Candida infection Drug interactions: - barbiturates, carbamazepine, cyclosporine, griseofulvin, penicillins, phenytoin, rifampin, tetracyclines

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998