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demeclocycline (Declomycin)
Tradename: Declomycin.
Indications:
- treatment of syndrome of inappropriate antidiuretic hormone (SIADH)
- bacterial infections due to susceptible organisms
- plague, tularemia, anthrax, brucellosis, actinomycosis, psittacosis, trachoma, typhus, rickettsialpox, borreliosis,
- skin or soft tissue infection
- acute otitis media
- oral infection
- gingivostomatitis
- upper respiratory tract infection
- pharyngitis, sinusitis
- lower respiratory tract infection
- pneumonia, bronchitis
- intra-abdominal infection
- gastrointestinal infection
- enterocolitis
- cholangitis
- urogenital infection
- syphilis, gonorrhea, chancroid, lymphogranuloma venereum, donovanosis, yaws
- proctitis
- eye disease
- inclusion conjunctivitis
Contraindications:
1) do NOT administer to children < 9 years of age
2) do NOT use in patients with hepatic cirrhosis
Caution: avoid prolonged exposure to sunlight
Dosage:
1) 150-300 mg PO BID
2) maximum: 1200 mg/day
Tabs: 150 & 300 mg.
Antimicrobial activity:
- Staphylococcus aureus
- Chlamydia
- Coxiella burnetii
- Neisseria gonorrhoeae
- Klebsiella
- Haemophilus influenzae
- Mycoplasma pneumoniae STAPHYLOCOCCUS_AUREUS
Adverse effects:
1) not common (1-10%)
- photosensitivity
- nausea/vomiting
- diarrhea
2) uncommon (< 1%)
- pericarditis, increased intracranial pressure, pruritus, exfoliative dermatitis, diabetes insipidus, pigmentation of nails, anorexia, abdominal cramps, paresthesia, renal failure, azotemia, anaphylaxis
Drug interactions: (see tetracycline)
Interactions
drug interactions
General
tetracycline (Achromycin, Sumycin, Bristacycline)
Properties
MISC-INFO: elimination route LIVER
KIDNEY
pregnancy-category D
safety in lactation -
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Deprecated Reference
- Department of Veterans Affairs, VA National Formulary