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delta opioid receptor; DOR-1 (OPRD1, OPRD)
Function:
- receptor for enkephalins
- highly stereoselective
- inhibits neurotransmitter release by Ca+2 currents & increasing K+ conductance.
- interacts with GPRASP1
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
endorphin receptor or opioid receptor
glycoprotein
Properties
SIZE: entity length = 372 aa
MW = 40 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-45}
MOTIF: N-glycosylation site {N18}
N-glycosylation site {N33}
transmembrane domain {46-75}
cytoplasmic loop {76-84}
transmembrane domain {85-102}
exoplasmic loop {103-124}
MOTIF: cysteine residue {C121}
MODIFICATION: cysteine residue {C198}
transmembrane domain {125-144}
cytoplasmic loop {145-174}
transmembrane domain {175-190}
exoplasmic loop {191-215}
MOTIF: cysteine residue {C198}
MODIFICATION: cysteine residue {C121}
transmembrane domain {216-238}
cytoplasmic loop {239-261}
transmembrane domain {262-284}
exoplasmic loop {285-293}
transmembrane domain {294-310}
cytoplasmic domain {311-372}
MOTIF: cysteine residue {C333}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 165195
UniProt P41143
Pfam PF00001
Kegg hsa:4985
References
- UniProt :accession P41143
- Wikipedia; Note: delta opioid receptor entry
http://en.wikipedia.org/wiki/delta_opioid_receptor
- VanDongen AM, Codina J, Olate J, Mattera R, Joho R,
Birnbaumer L, Brown AM.
Newly identified brain potassium channels gated by the guanine
nucleotide binding protein Go.
Science. 1988 Dec 9;242(4884):1433-7.
PMID: 3144040
- Reisine T, Bell GI.
Molecular biology of opioid receptors.
Trends Neurosci. 1993 Dec;16(12):506-10. Review.
PMID: 7509520