deficient antibody synthesis

Pathology: 1) deficiency in production of specific antibodies 2) immunization with common vaccines fails to elicit protective response including a) pneumovax b) influenza vaccine c) Haemophilus influenzae B vaccine d) tetanus toxoid Clinical manifestations: - frequent sinopulmonary infections Laboratory: - serum protein electrophoresis shows normal serum immunoglobulin

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998