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N,N-dimethyl-3-methylbenzamide (DEET, Ultrathon)
Pharmacology:
Tradenames: Off, Repel, Cutter
Indications: mosquito repellent (best on market 2002)
Dosage:
1) apply to skin & clothes [2]
2) 10-50% most adults [2]
3) 10% for children [2]
a) BID 6 months-2 years
b) TID > 2 years of age
4) up to 30% for children QD > 2 months of age [3]
Ultrathon: polymer form contains 25% DEET, lasts up to 8 hours
Avoid DEET/sunscreen combinations, sunscreen needs more frequent application
-> mean protection until time of 1st bite
concentration minutes until 1st bite (mean of 15)
24% 302
20% 234
6.6% 112
4.8% 88
Adverse effects:
1) excellent safety record after 40 years of use
2) excessive use associated with neurotoxicity [2]
-> limit concentration in children (see dosage)
General
aromatic compound
benzamide
insect repellant
Database Correlations
PUBCHEM cid=4284
References
- Journal Watch 22(15):116, 2002
Fradin MS & Day JF N Engl J Meed 347:13, 2002
- Prescriber's Letter 10(7):40 2003
Keeping Safe From West Nile Virus
Detail-Document#: 190709
(subscription needed) http://www.prescribersletter.com
- Prescriber's Letter 10(9):53 2003
Detail-Document#: 190911
(subscription needed) http://www.prescribersletter.com
- Prescriber's Letter 12(6): 2005
Keeping Safe From West Nile Virus
Detail-Document#: 210601
(subscription needed) http://www.prescribersletter.com