death effector domain-containing protein (death effector domain-containing testicular molecule, DEDPro1, FLDED-1, DEDD, DEDPRO1, DEFT, KE05)

Function: 1) scaffold protein that directs CASP3 to certain substrates - facilitates their ordered degradation during apoptosis 2) a role in CASP3 cleavage of KRT18 3) a role in degradation of intermediate filaments during apoptosis 4) a role in general transcription machinery in the nucleus 5) regulates activity of GTF3C3 (putative) 6) inhibits DNA transcription in vitro 7) interacts with CASP8, CASP10, KRT8, KRT18, CASP3, FADD 8) homodimerizes & heterodimerizes with DEDD2 9) exists predominantly in a mono- or diubiquitinated form Compartment: - cytoplasm - translocates to the nucleus during CD95-mediated apoptosis, localizes in the nucleoli - following apoptosis induction, the mono &/or diubiquitination form increases & forms filamentous structures that colocalize with KRT8 & KRT18 intermediate filament network in simple epithelial cells Alternative splicing: named isoforms=2 Expression: - widely expressed with highest levels in testis

Properties

SIZE: MW = 37 kD entity length = 318 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: death effector domain {25-103}

Database Correlations

OMIM 606841 UniProt O75618 Pfam PF01335

References

UniProt :accession O75618