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class B basic helix-loop-helix protein 3; bHLHB3; differentially expressed in chondrocytes protein 2; hDEC2; enhancer-of-split & hairy-related protein 1; SHARP-1 (BHLHB3, BHLHE41)
Function:
- transcriptional repressor
- represses both basal & activated transcription
Structure:
- homodimer
- contains 1 basic helix-loop-helix (bHLH)
- contains 1 Orange domain
Compartment: nucleus
Expression: -expressed in skeletal muscle & brain > pancreas & heart > placenta, lung, liver & kidney
Polymorphism:
- transcriptional repressor DEC2 regulates sleep length in mammals [2]
- hDEC2-P385R that is associated with a human short sleep phenotype
- 5 hours sleep may be sufficient
General
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 50 kD
entity length = 482 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 45-57
helix-loop-helix
NAME: helix-loop-helix
SITE: 58-100
FOR-BINDING-VIA: helix-loop-helix
Orange {131-166}
glycine-rich region {297-431}
Database Correlations
OMIM 606200
UniProt Q9C0J9
PFAM correlations
References
- UniProt :accession Q9C0J9
- He Y, Jones CR, Fujiki N et al
The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals.
Science 2009. 325(5942):866-870
PMID: 19679812 PMCID: PMC2884988 Free PMC article
https://science.sciencemag.org/content/325/5942/866