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death-inducing signaling complex (DISC)
Structure:
- consists of: CASP8, FADD, FAS, CASP8AP2
General
molecular complex
Properties
SUBUNITS: caspase-8
MOTIF: DED 1 {2-80}
DED 2 {100-177}
Ser phosphorylation site {S188}
Ser phosphorylation site {S219}
domain {220-479}
MOTIF: histidine residue {H317}
Tyr phosphorylation site {Y334}
QACQG
SITE: 358-362
MOTIF: cysteine residue {C360}
HOMOLOGY: caspase-1
FADD
Fas antigen
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
TNFR-Cys {47-83}
MOTIF: cysteine residue {C59}
MODIFICATION: cysteine residue {C73}
cysteine residue {C63}
MODIFICATION: cysteine residue {C82}
cysteine residue {C73}
MODIFICATION: cysteine residue {C59}
cysteine residue {C82}
MODIFICATION: cysteine residue {C63}
TNFR-Cys {84-127}
MOTIF: cysteine residue {C85}
MODIFICATION: cysteine residue {C101}
cysteine residue {C101}
MODIFICATION: cysteine residue {C85}
cysteine residue {C104}
MODIFICATION: cysteine residue {C119}
cysteine residue {C107}
MODIFICATION: cysteine residue {C127}
N-glycosylation site {N118}
cysteine residue {C119}
MODIFICATION: cysteine residue {C104}
cysteine residue {C127}
MODIFICATION: cysteine residue {C107}
TNFR-Cys {128-166}
MOTIF: cysteine residue {C129}
MODIFICATION: cysteine residue {C143}
N-glycosylation site {N136}
cysteine residue {C143}
MODIFICATION: cysteine residue {C129}
cysteine residue {C146}
MODIFICATION: cysteine residue {C157}
cysteine residue {C149}
MODIFICATION: cysteine residue {C165}
cysteine residue {C157}
MODIFICATION: cysteine residue {C146}
cysteine residue {C165}
MODIFICATION: cysteine residue {C149}
transmembrane domain {174-190}
Ser phosphorylation site {S209}
HIPK3 interaction {212-317}
MOTIF: Thr phosphorylation site {T214}
death domain
NAME: death domain
SITE: 230-314
CASP8-associated protein 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 1709-1982
FOR-BINDING-OF: nuclear receptor coactivator 2
References
UniProt :accession Q9UGP8
Components
CASP8-associated protein 2 (FLICE-associated huge protein, CASP8AP2, FLASH, KIAA1315, RIP25)
caspase-8; ICE-like apoptotic protease 5; MACH; MORT-1 associated CED-3 homolog; FLICE; FADD-like ICE; Mch5 (CASP8)
CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)