DEAD box protein 5; ATP-dependent RNA helicase DDX5; RNA helicase p68 (DDX5, G17P1, HELR, HLR1)

Function: - RNA-dependent ATPase activity - ATP hydrolysis isstimulated by single-stranded RNA - may be involved in pre-mRNA splicing - identified in the spliceosome C complex Structure: - Arg-502 is dimethylated, probably to asymmetric dimethylarginine - belongs to the DEAD box helicase family, DDX5/DBP2 subfamily - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain Compartment: nucleus, nucleolus

General

DEAD box ATP-dependent helicase phosphoprotein

Properties

SIZE: entity length = 614 aa MW = 69 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S30} Q motif {94-122} helicase NAME: helicase SITE: 125-300 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 138-145 Tyr phosphorylation site {Y202} DEAD/H box NAME: DEAD/H box SITE: 248-251 Tyr phosphorylation site {Y297} Helicase C-terminal {328-475} Ser phosphorylation site {S480} Thr phosphorylation site {T507} Ser phosphorylation site {S520}

Database Correlations

OMIM 180630 UniProt P17844 PFAM correlations Entrez Gene 1655 Kegg hsa:1655

References

UniProt :accession P17844