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pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; ATP-dependent RNA helicase #46; DEAH box protein 15 (DHX15, DBP1, DDX15)
Function:
- pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (putative)
- interacts with SSB/La
Structure:
- belongs to the DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus
Expression: ubiquitous
General
DEAH box ATP-dependent helicase
phosphoprotein
Properties
SIZE: entity length = 795 aa
MW = 91 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S15}
helicase
NAME: helicase
SITE: 147-313
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 160-167
DEAD/H box
NAME: DEAD/H box
SITE: 260-263
Helicase C-terminal {338-518}
MOTIF: Thr phosphorylation site {T476}
Database Correlations
OMIM 603403
UniProt O43143
PFAM correlations
Entrez Gene 1665
Kegg hsa:1665
ENZYME 3.6.4.13
References
UniProt :accession O43143