DNA-damage-inducible transcript 4-like protein (protein regulated in development & DNA damage response 2, REDD-2, HIF-1 responsive protein RTP801-like, DDIT4L, REDD2 RTP801L)

Function: - inhibits cell growth by regulating the FRAP1 pathway - upstream of the TSC1-TSC2 complex & downstream of AKT1 Structure: belongs to the DDIT4 family Compartment: cytoplasm (putative) Expression: - up-regulated in atherosclerotic plaques relative to healthy segments of the same artery - up-regulated by oxidized LDL & hypoxia in macrophages

Properties

GENERAL: uncharacterized protein SIZE: entity length = 193 aa MW = 22 kD FORM: DNA-damage-inducible transcript 4-like protein

Database Correlations

OMIM 607730 UniProt Q96D03 Pfam PF07809

References

UniProt :accession Q96D03