DNA-damage-inducible transcript 4 protein; protein regulated in development & DNA damage response 1; REDD-1; HIF-1 responsive protein RTP801 (DDIT4, REDD1, RTP801)

Function: - inhibits cell growth by regulating the FRAP1 pathway upstream of the TSC1-TSC2 complex & downstream of AKT1 - promotes neuronal cell death Structure: belongs to the DDIT4 family Compartment: cytoplasm Expression: - broadly expressed - lowest levels in brain, skeletal muscle & intestine - up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway - up-regulated by TP63 in primary keratinocytes, & down-regulated during keratinocyte differentiation - up-regulated upon DNA alkylation - up-regulated by amyloid beta-peptide & retinoic acid - up-regulated by hypoxia, via a PI3K & HIF1A-dependent but TP53/TP63-independent mechanism (at protein level) Pathology: - up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level)

Properties

GENERAL: uncharacterized protein SIZE: entity length = 232 aa MW = 25 kD FORM: DNA-damage-inducible transcript 4 protein

Database Correlations

OMIM 607729 UniProt Q9NX09 Pfam PF07809

References

UniProt :accession Q9NX09