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development & differentiation-enhancing factor-like 1; protein up-regulated in liver cancer 1 (DDEFL1, UPLC1, ASAP3)
Function: promotes cell proliferation
Structure:
- contains 2 ANK repeats
- contains 1 Arf-GAP domain
- contains 1 PH domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression: detected in lung, liver & blood leukocytes
Pathology:
- highly expressed in primary hepatocarcinoma
General
other protein
Properties
SIZE: MW = 99 kD
entity length = 903 aa
COMPARTMENT: cytoplasm
MOTIF: coiled coil {141-172}
coiled coil {248-275}
PH domain {302-394}
Arf-GAP domain
NAME: Arf-GAP domain
SITE: 426-551
MOTIF: Zn finger C4-type
SITE: 441-464
EFFECTOR-BOUND: Zn+2
ankyrin repeat
NAME: ankyrin repeat
SITE: 585-617
ankyrin repeat
NAME: ankyrin repeat
SITE: 621-650
serine-rich region {798-801}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q8TDY4
PFAM correlations
References
UniProt :accession Q8TDY4