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DNA damage-binding protein 1; damage-specific DNA-binding protein 1; UV-damaged DNA-binding factor; DDB p127 subunit; DNA damage-binding protein a; DDBa; UV-damaged DNA-binding protein 1; UV-DDB 1; Xeroderma pigmentosum group E-complementing protein; XPCe; XPE-binding factor; XPE-BF; HBV X-associated protein 1; XAP-1 (DDB1, XAP1)

forms heterodimer with DDB2; binds to pyrimidine dimers. defects associated with xeroderma pigmentosa group E Function: - required for DNA repair - binds to DDB2 to form the UV-DDB complex (UV-damaged DNA-binding protein complex) - also appears to function as a component of numerous distinct DDB1-CUL4-X-box (DCX) complex(es), E3 ubiquitin-protein ligase complexes which mediate the ubiquitination & subsequent proteasomal degradation of target proteins. a) DCX(DDB2) complex b) DCX(DTL) complex c) DCX(ERCC8) complex - protein modification; protein ubiquitination - ubiquitinated by CUL4A; subsequently degraded by ubiquitin- dependent proteolysis - interacts with AMBRA1, ATG16L1, BTRC, DCAF1, DCAF17, DCAF16, DCAF15, DDA1, DET1, DTL, ERCC8, FBXW5, FBXW8, GRWD1, DCAF6, KATNB1, NLE1, NUP43, PAFAH1B1, PHIP, PWP1, RBBP4, RBBP5, RBBP7, RFWD2, SNRNP40, VPRBP, WDR5, WDR5B, WDR12, DCAF4, DCAF5, DCAF11, WDR26, DCAF10, WDR39, DCAF12, WDR42, DCAF8, WDR53, WDR59, WDR61, DCAF7, WSB1, WSB2 & WDTC1 - interacts with NF2, TSC1 & TSC2 - interacts with simian virus 5 protein V & the HBV X protein - interaction with SV5 protein V may prevent the recruitment of DCAF proteins to DCX complexes Structure: belongs to the DDB1 family Compartment: - cytoplasm, nucleus - primarily cytoplasmic - translocates to the nucleus following UV irradiation & subsequently accumulates at sites of DNA damage

General

dna damage binding protein phosphoprotein

Properties

SIZE: entity length = 1140 aa MW = 127 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: CDT1 interaction {1-768} MOTIF: Thr phosphorylation site {T8} CUL4A interaction {391-709} Ser phosphorylation site {S757} Ser phosphorylation site {S766} CDT1/CUL4A interaction {771-1140}

Database Correlations

OMIM 600045 UniProt Q16531 Pfam PF03178 LOCUS-LINK correlations KEGG correlations

References

  1. UniProt :accession Q16531
  2. allelic variations of the XP genes http://www.xpmutations.org/
  3. NIEHS-SNPs http://egp.gs.washington.edu/data/ddb1/

Component-of

histone acetyltransferase complex