dynactin (subunit 2 dynactin 50 KD subunit, dynamitin, dynactin p50, 50 kD dynein-associated polypeptide, DCTN-50, DCTN2, DCTN50)

Function: - subunit of dynactin - modulates cytoplasmic dynein binding to an organelle, - role in prometaphase chromosome alignment & spindle organization during mitosis - role in synapse formation during brain development (putative) - interacts with BICD2 (putative) - interacts with MAPRE1 Structure: belongs to the dynactin subunit 2 family Compartment: cytoplasm, cytoskeleton, peripheral membrane

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 401 aa MW = 44 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S83} Tyr phosphorylation site {Y86} coiled coil {99-132} coiled coil {214-244} coiled coil {379-399}

Database Correlations

OMIM 607376 UniProt Q13561 Pfam PF04912 Kegg hsa:1054

References

UniProt :accession Q13561