mRNA-decapping enzyme 2; hDpc; nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20 (DCP2, NUDT20)

Function: 1) degradation of mRNAs a) normal mRNA turnover b) nonsense-mediated mRNA decay 2) removes the 7-methyl guanine cap structure from mRNA, yields 5'-phosphorylated mRNA fragment & 7m-GDP 3) higher activity towards mRNAs that lack a polyA tail 4) no activity towards a cap structure without RNA 5) component of mRNA decay complex 6) interacts with DCP1A, DPC1B, RENT1, RENT2 & RENT3B Cofactor: Mn+2 or Mg⁺² Compartment: - associates with polysomes - predominantly cytoplasmic, discrete foci - minor amount nuclear

General

mRNA decapping enzyme nucleoside diphosphate-linked moiety X motif; Nudix hydrolase family (NUDT)

Properties

SIZE: entity length = 420 aa MW = 48 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Nudix hydrolase {95-226} MOTIF: Nudix box {129-150} manganese [Mn]-binding site SITE: 144-144 manganese [Mn]-binding site SITE: 148-148 Ser phosphorylation site {S246} Ser phosphorylation site {S247} Ser phosphorylation site {S249} Ser phosphorylation site {S276} Ser phosphorylation site {S284} Ser phosphorylation site {S347}

Database Correlations

OMIM 609844 UniProt Q8IU60 PFAM correlations Entrez Gene 167227 Kegg hsa:167227

References

UniProt :accession Q8IU60