Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor (PCBD2, DCOH2, DCOHM)

Function: 1) tetrahydrobiopterin biosynthesis 2) prevents formation of 7-pterins 3) accelerates formation of quinonoid-BH2 4) regulates dimerization of homeodomain protein HNF1-alpha & enhances its transcriptional activity 5) interacts with DYRK1B (6R)-6-(L-erythro-1,2-dihydroxypropyl)- 5,6,7,8-tetrahydro-4a-hydroxypterin PCBD2 (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H₂O Structure: - homotetramer - belongs to the pterin-4-alpha-carbinolamine dehydratase family

Properties

SIZE: entity length = 130 aa MW = 14 kD MOTIF: active site

Database Correlations

UniProt Q9H0N5 Pfam PF01329 ENZYME 4.2.1.96

References

UniProt :accession Q9H0N5