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pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; DEAH-box protein 16; ATP-dependent RNA helicase #3 (DHX16, DBP2, DDX16, KIAA0577)
Function:
- probable ATP-binding RNA helicase involved in pre-mRNA splicing
- ATP + H2O = ADP + phosphate
Structure:
- belongs to the DEAD box helicase family, DEAH subfamily, DDX16/PRP8 sub-subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus
General
DEAD box ATP-dependent helicase
phosphoprotein
splicing factor; snRNP-associated protein
Properties
SIZE: entity length = 1041 aa
MW = 119 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S103}
Ser phosphorylation site {S106}
Ser phosphorylation site {S107}
Ser phosphorylation site {S160}
helicase
NAME: helicase
SITE: 409-573
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 422-429
DEAD/H box
NAME: DEAD/H box
SITE: 520-523
Helicase C-terminal {598-771}
Database Correlations
OMIM 603405
UniProt O60231
PFAM correlations
Entrez Gene 8449
Kegg hsa:8449
ENZYME 3.6.4.13
References
UniProt :accession O60231