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protein DBF4 homolog (activator of S phase Kinase, DBF4, ASK, dumbell former 4)
Function:
1) regulatory subunit for CDC7, activates kinase activity
2) required for entry into S phase
3) CDC7-DBF4 selectively phosphorylates MCM2 subunit of chromatin-associated MCM complex
4) initiation of DNA replication during cell cycle
5) forms a complex with CDC7
6) interacts with MEN1, MCM2, ORC2, ORC4 & ORC6
Structure:
- contains 2 BRCT domains
- contains 1 DBF4-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in testis, thymus, most cancer cells lines
- induced in G1 phase at low level, increased during G1-S phase & remains high during S phase & G2-M phase
General
zinc finger protein
Properties
SIZE: MW = 77 kD
entity length = 674 aa
MOTIF: BRCT 1 {40-128}
BRCT 2 {154-179}
Zinc finger
NAME: Zinc finger
SITE: 289-336
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 604281
UniProt Q9UBU7
PFAM correlations
References
UniProt :accession Q9UBU7