deleted in azoospermia-like (DAZ-like autosomal, deleted in azoospermia-like 1, DAZ homolog, SPGY-like-autosomal, DAZL, DAZH, DAZL, DAZLA, SPGYLA)

Function: 1) RNA-binding protein 2) essential for gametogenesi 3) role iin spermatogenesis 4) binds 3'UTR of mRNA & regulates translation of key transcripts (putative) 5) forms heterodimer with DAZ 6) interacts with BOLL, DAZAP1, DAZAP2, PUM2 - DAZ-like domain mediates interaction with DAZAP1, DAZAP2 Structure: - homodimer & heterodimer with DAZ - belongs to the RNP DAZ family - contains 1 DAZ-like domain contains 1 RRM domain (RNA recognition motif) Compartment: - cytoplasm, nucleus, predominantly cytoplasmic - nuclear in spermatogonia until near the end of meiotic prophase, cytoplasmic then onward Expression: testis specific Pathology: - defects in DAZL may be a cause of infertility due to oligozoospermia & non obstructive azoospermia

Properties

SIZE: MW = 33 kD entity length = 295 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 40-115 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif homodimerization {80-132} DAZ-like {167-190}

Database Correlations

OMIM 601486 MORBIDMAP 601486 UniProt Q92904 Pfam PF00076

References

UniProt :accession Q92904