Search
dasatinib (Sprycel)
Tradename: Sprycel
Indications:
1) chronic myeloid leukemia (CML)
2) Philadelphia chromosome + acute lymphoblastic leukemia (ALL)
3) for patients not responding to other therapies
Dosage: usual dose is 70 mg PO BID
Tabs: 20, 50, 70, 80, 100, 140 mg [5]
Pharmacokinetics:
- metabolized by CYP3A4
Adverse effects:
1) bleeding
2) diarrhea
3) skin rash
4) infections
5) headache
6) fatigue
7) edema
8) nausea
9) anemia
10) neutropenia
11) thrombocytopenia
12) abnormal liver function tests
13) pulmonary hypertension (rare) [3,4]
14) pericardial effusion [4]
15) pleural effusion [4]
Drug interactions:
1) levels may be increased by drugs that inhibit cyt P450 3A4
2) levels may be decreased by drugs that induce cyt P450 3A4
- St John's wort, carbamazepine, phenobarbital, phenytoin, primidone, others
3) proton pump inhibitors may decrease absorption of dasatinib
Mechanism of action:
1) tyrosine kinase inhibitor
2) inhibits proliferation of abnormal leukocytes
3) said to act similarly to imatinib (Gleevec)
4) may inhibit bcl-abl
5) inhibits CSF1R Bristol-Myers Squibb Cost $5000/month 2006
Interactions
drug adverse effects of tyrosine kinase inhibitor(s)
General
antineoplastic tyrosine kinase inhibitor
small inhibitory antineoplastic agent (ib drug)
Properties
INHIBITS: protein kinase
Database Correlations
PUBCHEM cid=3062316
References
- Prescriber's Letter 13(8): 2006
FDA Approves Sprycel, a New Treatment for a Rare Type of
Leukemia
Detail-Document#: 220812
(subscription needed) http://www.prescribersletter.com
- Cortes JE et al
Results of dasatinib therapy in patients with early chronic-
phase chronic myeloid leukemia.
J Clin Oncol 2010 Jan 20; 28:398.
PMID: 20008620
- FDA MedWatch: 10/11/2011
Sprycel (dasatinib): Drug Safety Communication -
Risk of Pulmonary Arterial Hypertension
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm275176.htm
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- dasatinib (Rx)
Medscape
https://reference.medscape.com/drug/sprycel-dasatinib-342199