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protein phosphatase 1 regulatory subunit 1B; DARPP-32; dopamine- & cAMP-regulated neuronal phosphoprotein (PPP1R1B, DARPP32)
Function:
- associates & blocks phosphatase-1
- dopamine- & cyclic AMP-regulated neuronal phosphoprotein
- phosphorylation of Thr-34 is required for activity
Structure: belongs to the protein phosphatase inhibitor 1 family
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- highly concentrated in basal ganglia
- localized to neurons with D1 dopamine receptors
- not associated with particular neurotransmitter type
Interactions
molecular events
General
protein phosphatase-1 regulatory subunit
Properties
COMPARTMENT: cytoplasm
INHIBITS: phosphatase-1
SIZE: entity length = 204 aa
MW = 23 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr phosphorylation site {T34}
Thr phosphorylation site {T75}
Ser phosphorylation site {S102}
acidic region {119-136}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S198}
Database Correlations
OMIM 604399
UniProt Q9UD71
Pfam PF05395
Entrez Gene 84152
Kegg hsa:84152
References
- UniProt :accession Q9UD71
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/PPP1R1BID44096ch17q12.html
- ) Armstrong DL
Calcium channel regulation by calcineurin, a Ca+2-activated
phosphatase in mammalian brain
TINS 12(3):117 1989
PMID: 2469218
- Nestler & Greengard, Basic Neurochemistry 4th ed. p393-4