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dapivirine

Indications: - preexposure prophylaxis for HIV1 delivered in a vaginal ring* * 56% efficacy among women > 21 years if age but no protection i in those < 21 years - difference could be explained by poor adherence among younger women Mechanism of action: - non-nucleoside reverse transcriptase inhibitor

Interactions

drug adverse effects of antiretroviral agents

General

non-nucleoside reverse transcriptase inhibitor (NNRTI)

References

  1. Baeten JM, Palanee-Phillips T, Brown ER et al. Use of a vaginal ring containing dapivirine for HIV-1 prevention in women. N Engl J Med 2016 Feb 22 PMID: 26900902 Free full text http://www.nejm.org/doi/10.1056/NEJMoa1506110