death-associated protein kinase 1; DAP kinase 1 (DAPK1, DAPK)

Function: - Ca⁺²/calmodulin-dependent serine/threonine kinase - acts as a positive regulator of apoptosis - mediator of gamma-interferon induced cell death - negatively regulated by autophosphorylation on Ser-308 Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily - contains 10 ANK repeats - contains 1 death domain - contains 1 protein kinase domain Compartment: - cytoplasm - colocalizes with the actin filament system Alternative splicing: named isoforms=2 Expression: - up-regulated following treatment with interferon-gamma

General

ankyrin repeat domain protein (ANKRD) Ca+2/calmodulin-dependent protein kinase (CaM kinase) pro apoptotic protein

Properties

SIZE: entity length = 1430 aa MW = 160 kD COMPARTMENT: cytoplasm MOTIF: kinase domain SITE: 13-275 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 19-27 ATP-binding site NAME: ATP-binding site SITE: 42-42 ATP-binding site NAME: ATP-binding site SITE: 94-96 ATP-binding site NAME: ATP-binding site SITE: 100-100 aspartate residue {D139} ATP-binding site NAME: ATP-binding site SITE: 161-161 binding site SITE: 267-334 FOR-BINDING-OF: calmodulin MOTIF: Ser phosphorylation site {S308} ankyrin repeat NAME: ankyrin repeat SITE: 378-407 ankyrin repeat NAME: ankyrin repeat SITE: 411-440 ankyrin repeat NAME: ankyrin repeat SITE: 444-473 ankyrin repeat NAME: ankyrin repeat SITE: 477-506 ankyrin repeat NAME: ankyrin repeat SITE: 510-539 ankyrin repeat NAME: ankyrin repeat SITE: 543-572 ankyrin repeat NAME: ankyrin repeat SITE: 576-605 ankyrin repeat NAME: ankyrin repeat SITE: 609-638 ankyrin repeat NAME: ankyrin repeat SITE: 875-904 ankyrin repeat NAME: ankyrin repeat SITE: 1162-1196 death domain NAME: death domain SITE: 1312-1396 STATE: active state

Database Correlations

OMIM 600831 UniProt P53355 PFAM correlations Entrez Gene 1612 Kegg hsa:1612 ENZYME 2.7.11.1